inSciences
  • Home
  • Human
    • All
    • Diseases
    • Health & Medicine
    • Mental Health
    • Neurology
    • Psychology
    • Sensors
    Roche develops new serology test to detect COVID-19 antibodies

    Roche develops new serology test to detect COVID-19 antibodies

    Novartis announces data in Neurology reinforcing the real-world and long-term effectiveness and safety of Aimovig® as a preventive treatment across the full spectrum of migraine

    Novartis announces data in Neurology reinforcing the real-world and long-term effectiveness and safety of Aimovig® as a preventive treatment across the full spectrum of migraine

    EMA review of Picato concludes medicine’s risks outweigh its benefits

    EMA review of Picato concludes medicine’s risks outweigh its benefits

    Dance With Your Grandma (after COVID-19 of course)

    Dance With Your Grandma (after COVID-19 of course)

    Covid-19 mortality highly influenced by age demographics

    Covid-19 mortality highly influenced by age demographics

    Alarming Abusive Head Trauma Revealed in Computational Simulation Impact Study

    Increased Rate of Infections May Indicate a Future Cancer Diagnosis

    Remdesivir improved majority of patients hospitalized with severe COVID-19

    Remdesivir improved majority of patients hospitalized with severe COVID-19

    Blood Test May Help Doctors Catch Pancreatic Cancer Early

    Blood Test May Help Doctors Catch Pancreatic Cancer Early

    Mental health and brain research must be a higher priority in global response to tackle COVID-19 pandemic

    Mental health and brain research must be a higher priority in global response to tackle COVID-19 pandemic

    Trending Tags

    • Earth
      • All
      • Archaeology
      • Climate
      • Environment
      • Oceans
      • Seismology
      Unusually Clear Skies Drove Record Loss of Greenland Ice in 2019

      Unusually Clear Skies Drove Record Loss of Greenland Ice in 2019

      Volcanic CO2 emissions helped trigger Triassic climate change

      Volcanic CO2 emissions helped trigger Triassic climate change

      Timing of Large Earthquakes Follows a “Devil’s Staircase” Pattern

      Timing of Large Earthquakes Follows a “Devil’s Staircase” Pattern

      Neanderthal cord weaver

      Neanderthal cord weaver

      New Species Discovered During Exploration of Abyssal Deep-Sea Canyons off Ningaloo

      New Species Discovered During Exploration of Abyssal Deep-Sea Canyons off Ningaloo

      Bristol leads archaeologists on 5,000-year-old egg hunt

      Bristol leads archaeologists on 5,000-year-old egg hunt

      Climate change could cause sudden biodiversity losses worldwide

      Climate change could cause sudden biodiversity losses worldwide

      Data From NASA’s Cassini May Explain Saturn’s Atmospheric Mystery

      Data From NASA’s Cassini May Explain Saturn’s Atmospheric Mystery

      Sulfur ‘Spices’ Alien Atmospheres

      Sulfur ‘Spices’ Alien Atmospheres

      Trending Tags

      • Space
        • All
        • Astronomy
        Texas-Led Team Finds Earth-Sized, Habitable Zone Planet Hidden in Early NASA Kepler Data

        Texas-Led Team Finds Earth-Sized, Habitable Zone Planet Hidden in Early NASA Kepler Data

        ESO Telescope Sees Star Dance Around Supermassive Black Hole, Proves Einstein Right

        ESO Telescope Sees Star Dance Around Supermassive Black Hole, Proves Einstein Right

        Beacon In Space

        Beacon In Space

        Beacon in space

        Beacon in space

        Clemson researchers capture first-ever photographic proof of power-packed jet emerging from colliding galaxies

        Clemson researchers capture first-ever photographic proof of power-packed jet emerging from colliding galaxies

        The Milky Way’s satellites help reveal link between dark matter halos and galaxy formation

        The Milky Way’s satellites help reveal link between dark matter halos and galaxy formation

        Data From NASA’s Cassini May Explain Saturn’s Atmospheric Mystery

        Data From NASA’s Cassini May Explain Saturn’s Atmospheric Mystery

        Trending Tags

        • Technology
          • All
          • Artificial Intelligence
          • Computer Science
          • Imaging Technology
          • Photonics
          Lighting the Way to Safer Heart Procedures

          Lighting the Way to Safer Heart Procedures

          3D Fusion Imaging Improves Coronary Artery Disease Diagnosis

          3D Fusion Imaging Improves Coronary Artery Disease Diagnosis

          Long Spaceflights Affect Astronaut Brain Volume

          Long Spaceflights Affect Astronaut Brain Volume

          The Power of Light – Ultraviolet LEDs prove effective in eliminating coronavirus from surfaces and, potentially, air and water

          The Power of Light – Ultraviolet LEDs prove effective in eliminating coronavirus from surfaces and, potentially, air and water

          Artificial Intelligence Can Help Some Businesses But May Not Work For Others

          Artificial Intelligence Can Help Some Businesses But May Not Work For Others

          Reducing Delays In Wireless Networks

          Reducing Delays In Wireless Networks

          Successful development of photovoltaic commercialization technology with improved quantum dot efficiency

          Successful development of photovoltaic commercialization technology with improved quantum dot efficiency

          To Tune Up Your Quantum Computer, Better Call an AI Mechanic

          To Tune Up Your Quantum Computer, Better Call an AI Mechanic

          Trending Tags

          • Physics
            • All
            • Astrophysics
            • Chemistry
            • Materials Science
            • Nanotechnology
            • Physics
            • Quantum Physics
            Potential energy saving solution for making vital chemicals

            Potential energy saving solution for making vital chemicals

            Scientists Discover Brightest Supernova Ever Seen

            Scientists Discover Brightest Supernova Ever Seen

            Acidic alert

            Acidic alert

            Texas-Led Team Finds Earth-Sized, Habitable Zone Planet Hidden in Early NASA Kepler Data

            Texas-Led Team Finds Earth-Sized, Habitable Zone Planet Hidden in Early NASA Kepler Data

            Finding the beat: New discovery settles a long-standing debate about photovoltaic materials

            Finding the beat: New discovery settles a long-standing debate about photovoltaic materials

            With a heavy heart: how men and women develop heart disease differently

            With a heavy heart: how men and women develop heart disease differently

            Untwisting plastics for charging Internet-of-things devices

            Untwisting plastics for charging Internet-of-things devices

            Applying mathematics to accelerate predictions for capturing fusion energy

            Applying mathematics to accelerate predictions for capturing fusion energy

            New boron material of high hardness created by plasma chemical vapor deposition

            New boron material of high hardness created by plasma chemical vapor deposition

            Trending Tags

            • Business
              • All
              • Business
              • Economics
              Mutual Funds With Lower Tax Burdens Have Higher Returns

              Mutual Funds With Lower Tax Burdens Have Higher Returns

              New Research Finds Rising Between-Workplace Inequalities in the U.S. and other High Income Countries

              New Research Finds Rising Between-Workplace Inequalities in the U.S. and other High Income Countries

              Artificial Intelligence Can Help Some Businesses But May Not Work For Others

              Artificial Intelligence Can Help Some Businesses But May Not Work For Others

              Older Entrepreneurs as Successful as Their Younger Counterparts, Study Reveals

              Older Entrepreneurs as Successful as Their Younger Counterparts, Study Reveals

              Trending Tags

              No Result
              View All Result
              inSciences
              • Home
              • Human
                • All
                • Diseases
                • Health & Medicine
                • Mental Health
                • Neurology
                • Psychology
                • Sensors
                Roche develops new serology test to detect COVID-19 antibodies

                Roche develops new serology test to detect COVID-19 antibodies

                Novartis announces data in Neurology reinforcing the real-world and long-term effectiveness and safety of Aimovig® as a preventive treatment across the full spectrum of migraine

                Novartis announces data in Neurology reinforcing the real-world and long-term effectiveness and safety of Aimovig® as a preventive treatment across the full spectrum of migraine

                EMA review of Picato concludes medicine’s risks outweigh its benefits

                EMA review of Picato concludes medicine’s risks outweigh its benefits

                Dance With Your Grandma (after COVID-19 of course)

                Dance With Your Grandma (after COVID-19 of course)

                Covid-19 mortality highly influenced by age demographics

                Covid-19 mortality highly influenced by age demographics

                Alarming Abusive Head Trauma Revealed in Computational Simulation Impact Study

                Increased Rate of Infections May Indicate a Future Cancer Diagnosis

                Remdesivir improved majority of patients hospitalized with severe COVID-19

                Remdesivir improved majority of patients hospitalized with severe COVID-19

                Blood Test May Help Doctors Catch Pancreatic Cancer Early

                Blood Test May Help Doctors Catch Pancreatic Cancer Early

                Mental health and brain research must be a higher priority in global response to tackle COVID-19 pandemic

                Mental health and brain research must be a higher priority in global response to tackle COVID-19 pandemic

                Trending Tags

                • Earth
                  • All
                  • Archaeology
                  • Climate
                  • Environment
                  • Oceans
                  • Seismology
                  Unusually Clear Skies Drove Record Loss of Greenland Ice in 2019

                  Unusually Clear Skies Drove Record Loss of Greenland Ice in 2019

                  Volcanic CO2 emissions helped trigger Triassic climate change

                  Volcanic CO2 emissions helped trigger Triassic climate change

                  Timing of Large Earthquakes Follows a “Devil’s Staircase” Pattern

                  Timing of Large Earthquakes Follows a “Devil’s Staircase” Pattern

                  Neanderthal cord weaver

                  Neanderthal cord weaver

                  New Species Discovered During Exploration of Abyssal Deep-Sea Canyons off Ningaloo

                  New Species Discovered During Exploration of Abyssal Deep-Sea Canyons off Ningaloo

                  Bristol leads archaeologists on 5,000-year-old egg hunt

                  Bristol leads archaeologists on 5,000-year-old egg hunt

                  Climate change could cause sudden biodiversity losses worldwide

                  Climate change could cause sudden biodiversity losses worldwide

                  Data From NASA’s Cassini May Explain Saturn’s Atmospheric Mystery

                  Data From NASA’s Cassini May Explain Saturn’s Atmospheric Mystery

                  Sulfur ‘Spices’ Alien Atmospheres

                  Sulfur ‘Spices’ Alien Atmospheres

                  Trending Tags

                  • Space
                    • All
                    • Astronomy
                    Texas-Led Team Finds Earth-Sized, Habitable Zone Planet Hidden in Early NASA Kepler Data

                    Texas-Led Team Finds Earth-Sized, Habitable Zone Planet Hidden in Early NASA Kepler Data

                    ESO Telescope Sees Star Dance Around Supermassive Black Hole, Proves Einstein Right

                    ESO Telescope Sees Star Dance Around Supermassive Black Hole, Proves Einstein Right

                    Beacon In Space

                    Beacon In Space

                    Beacon in space

                    Beacon in space

                    Clemson researchers capture first-ever photographic proof of power-packed jet emerging from colliding galaxies

                    Clemson researchers capture first-ever photographic proof of power-packed jet emerging from colliding galaxies

                    The Milky Way’s satellites help reveal link between dark matter halos and galaxy formation

                    The Milky Way’s satellites help reveal link between dark matter halos and galaxy formation

                    Data From NASA’s Cassini May Explain Saturn’s Atmospheric Mystery

                    Data From NASA’s Cassini May Explain Saturn’s Atmospheric Mystery

                    Trending Tags

                    • Technology
                      • All
                      • Artificial Intelligence
                      • Computer Science
                      • Imaging Technology
                      • Photonics
                      Lighting the Way to Safer Heart Procedures

                      Lighting the Way to Safer Heart Procedures

                      3D Fusion Imaging Improves Coronary Artery Disease Diagnosis

                      3D Fusion Imaging Improves Coronary Artery Disease Diagnosis

                      Long Spaceflights Affect Astronaut Brain Volume

                      Long Spaceflights Affect Astronaut Brain Volume

                      The Power of Light – Ultraviolet LEDs prove effective in eliminating coronavirus from surfaces and, potentially, air and water

                      The Power of Light – Ultraviolet LEDs prove effective in eliminating coronavirus from surfaces and, potentially, air and water

                      Artificial Intelligence Can Help Some Businesses But May Not Work For Others

                      Artificial Intelligence Can Help Some Businesses But May Not Work For Others

                      Reducing Delays In Wireless Networks

                      Reducing Delays In Wireless Networks

                      Successful development of photovoltaic commercialization technology with improved quantum dot efficiency

                      Successful development of photovoltaic commercialization technology with improved quantum dot efficiency

                      To Tune Up Your Quantum Computer, Better Call an AI Mechanic

                      To Tune Up Your Quantum Computer, Better Call an AI Mechanic

                      Trending Tags

                      • Physics
                        • All
                        • Astrophysics
                        • Chemistry
                        • Materials Science
                        • Nanotechnology
                        • Physics
                        • Quantum Physics
                        Potential energy saving solution for making vital chemicals

                        Potential energy saving solution for making vital chemicals

                        Scientists Discover Brightest Supernova Ever Seen

                        Scientists Discover Brightest Supernova Ever Seen

                        Acidic alert

                        Acidic alert

                        Texas-Led Team Finds Earth-Sized, Habitable Zone Planet Hidden in Early NASA Kepler Data

                        Texas-Led Team Finds Earth-Sized, Habitable Zone Planet Hidden in Early NASA Kepler Data

                        Finding the beat: New discovery settles a long-standing debate about photovoltaic materials

                        Finding the beat: New discovery settles a long-standing debate about photovoltaic materials

                        With a heavy heart: how men and women develop heart disease differently

                        With a heavy heart: how men and women develop heart disease differently

                        Untwisting plastics for charging Internet-of-things devices

                        Untwisting plastics for charging Internet-of-things devices

                        Applying mathematics to accelerate predictions for capturing fusion energy

                        Applying mathematics to accelerate predictions for capturing fusion energy

                        New boron material of high hardness created by plasma chemical vapor deposition

                        New boron material of high hardness created by plasma chemical vapor deposition

                        Trending Tags

                        • Business
                          • All
                          • Business
                          • Economics
                          Mutual Funds With Lower Tax Burdens Have Higher Returns

                          Mutual Funds With Lower Tax Burdens Have Higher Returns

                          New Research Finds Rising Between-Workplace Inequalities in the U.S. and other High Income Countries

                          New Research Finds Rising Between-Workplace Inequalities in the U.S. and other High Income Countries

                          Artificial Intelligence Can Help Some Businesses But May Not Work For Others

                          Artificial Intelligence Can Help Some Businesses But May Not Work For Others

                          Older Entrepreneurs as Successful as Their Younger Counterparts, Study Reveals

                          Older Entrepreneurs as Successful as Their Younger Counterparts, Study Reveals

                          Trending Tags

                          No Result
                          View All Result
                          inSciences
                          No Result
                          View All Result
                          Home Life Science Genetics

                          Switching on a key cancer gene could provide first curative treatment for heart disease

                          by Insciences
                          April 14, 2020
                          in Genetics
                          0
                          Switching on a key cancer gene could provide first curative treatment for heart disease
                          Share on FacebookShare on Twitter

                          Researchers trying to turn off a gene that allows cancers to spread have made a surprising U-turn. By making the gene overactive and functional in the hearts of mice, they have triggered heart cell regeneration.

                          Since adult hearts cannot usually repair themselves once damaged, harnessing the power of this gene represents major progress towards the first curative treatment for heart disease. 

                          “This is really exciting because scientists have been trying to make heart cells proliferate for a long time. None of the current heart disease treatments are able to reverse degeneration of the heart tissue – they only slow progression of the disease. Now we’ve found a way to do it in a mouse model,” said Dr Catherine Wilson, a researcher in the University of Cambridge’s Department of Pharmacology, who led the study.

                          The cell cycle – through which cells make copies of themselves – is tightly controlled in mammalian cells. Cancer develops when cells start to replicate themselves uncontrollably, and the Myc gene plays a key role in the process. Myc is known to be overactive in the vast majority of cancers, so targeting this gene is one of the highest priorities in cancer research. Much recent research has focused on trying to take control of Myc as a means of cancer therapy.

                          “The inability of the heart to regenerate itself is a significant unmet clinical need”

                          Catherine Wilson

                          When the researchers made Myc overactive in a mouse model, they saw its cancerous effects in organs including the liver and lungs: huge amount of cells started replicating over the course of a few days. But in the heart, nothing much happened. 

                          They found that Myc-driven activity in heart muscle cells is critically dependent on the level of another protein called Cyclin T1, made by a gene called Ccnt1, within the cells. When the Ccnt1 and Myc genes are expressed together, the heart switches into a regenerative state and its cells start to replicate. The results are published today in the journal Nature Communications.

                          “When these two genes were overexpressed together in the heart muscle cells of adult mice we saw extensive cell replication, leading to a large increase in the number of heart muscle cells,” said Wilson. 

                          Heart failure affects around 23 million people worldwide each year, and there is currently no cure. After a heart attack, an adult human heart can lose up to one billion heart muscle cells – called cardiomyocytes. Unlike many other organs in the body, the adult heart can’t regenerate itself, so these cells are never replaced. Their loss reduces the strength of the heart and causes scar formation, heart failure and ultimately death. 

                          Using a next generation sequencing technology called ChIP, the researchers were able to watch the action of Myc in the heart cells. Myc produces a protein – called a transcription factor – that binds to the DNA in specific cells and activates gene expression. But despite the protein binding successfully, the heart cells didn’t start to replicate themselves because the protein could not activate gene expression. Another protein vital to gene expression, Cyclin T1, was deficient in the heart. Adding it to the cells with the overactive Myc caused the cells to start proliferating.

                          “None of the current treatment options can reverse the degeneration of heart tissue. The inability of the heart to regenerate itself is a significant unmet clinical need,” said Wilson. “We found that even when Myc is switched on in a heart, the other tools aren’t there to make it work, which may be one of the reasons heart cancer is so extremely rare. Now we know what’s missing, we can add it and make the cells replicate.”

                          As the world’s population grows and the prevalence of heart failure increases, the cost of patient care is anticipated to increase dramatically. The researchers hope to develop their finding into a genetic therapy for the treatment of heart disease. “We want to use short-term, switchable technologies to turn on Myc and Cyclin T1 in the heart. That way we won’t leave any genetic footprint that might inadvertently lead to cancer formation,” said Wilson.

                          This research was funded by Cancer Research UK.

                          Reference:
                          Bywater, M. J. et al: ‘Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity.’ Nature Communications, April 2020. DOI: 10.1038/s41467-020-15552-x

                          Source: University of Cambridge

                          Tags: cardiomyocytesCcnt1ChIPCyclin T1GenesHeartHeart diseaseMycMyc geneMyc transcriptionsequencing technology
                          Next Post
                          Traditional Vegetable Diet Lowers The Risk of Premature Babies

                          Traditional Vegetable Diet Lowers The Risk of Premature Babies

                          Spider Venom Key To Pain Relief Without Side-Effects

                          Spider Venom Key To Pain Relief Without Side-Effects

                          The Power of Light – Ultraviolet LEDs prove effective in eliminating coronavirus from surfaces and, potentially, air and water

                          The Power of Light - Ultraviolet LEDs prove effective in eliminating coronavirus from surfaces and, potentially, air and water

                          Please login to join discussion

                          Recent News

                          Potential energy saving solution for making vital chemicals

                          Potential energy saving solution for making vital chemicals

                          April 18, 2020
                          Scientists Discover Brightest Supernova Ever Seen

                          Scientists Discover Brightest Supernova Ever Seen

                          April 17, 2020

                          Category

                          • Animals
                          • Applied physics
                          • Archaeology
                          • Artificial Intelligence
                          • Astronomy
                          • Astrophysics
                          • Biochemistry
                          • Biology
                          • Biomechanics
                          • Biomedical Engineering
                          • Business
                          • Business
                          • Cancer
                          • Cell Biology
                          • Chemistry
                          • Climate
                          • Computer Science
                          • Diseases
                          • Earth Science
                          • Economics
                          • Engineering
                          • Environment
                          • General
                          • Genetics
                          • Health & Medicine
                          • Human Science
                          • Imaging Technology
                          • Immunology
                          • Life Science
                          • Materials Science
                          • Mechanical engineering
                          • Mental Health
                          • Molecular Biology
                          • Nanotechnology
                          • Neurology
                          • Neuroscience
                          • Nutrition
                          • Oceans
                          • Pharmaceutical Sciences
                          • Photonics
                          • Physical Science
                          • Physics
                          • Plants
                          • Psychology
                          • Quantum Physics
                          • Radiology
                          • Seismology
                          • Sensors
                          • Sociology
                          • Space
                          • Sports
                          • Stem Cells
                          • Technology

                          About Us

                          Insciences is a non-profit organization based in Switzerland and hosted by ‘nextron‘. Insciences is an international, free-access sciences news website dedicated solely to experts in science fields such as researchers, professors, doctors, lecturers and PhD students from all around the world.

                          • Privacy Policy

                          © 2020 Insciences Organisation Switzerland

                          No Result
                          View All Result
                          • Home
                          • General
                          • Human Science
                            • Health & Medicine
                          • Earth Science
                            • Environment
                          • Space
                          • Technology
                            • Artificial Intelligence
                          • Physics
                          • Chemistry
                          • Business
                            • Business
                            • Economics

                          © 2020 Insciences Organisation Switzerland