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                Roche develops new serology test to detect COVID-19 antibodies

                Roche develops new serology test to detect COVID-19 antibodies

                Novartis announces data in Neurology reinforcing the real-world and long-term effectiveness and safety of Aimovig® as a preventive treatment across the full spectrum of migraine

                Novartis announces data in Neurology reinforcing the real-world and long-term effectiveness and safety of Aimovig® as a preventive treatment across the full spectrum of migraine

                EMA review of Picato concludes medicine’s risks outweigh its benefits

                EMA review of Picato concludes medicine’s risks outweigh its benefits

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                Dance With Your Grandma (after COVID-19 of course)

                Covid-19 mortality highly influenced by age demographics

                Covid-19 mortality highly influenced by age demographics

                Alarming Abusive Head Trauma Revealed in Computational Simulation Impact Study

                Increased Rate of Infections May Indicate a Future Cancer Diagnosis

                Remdesivir improved majority of patients hospitalized with severe COVID-19

                Remdesivir improved majority of patients hospitalized with severe COVID-19

                Blood Test May Help Doctors Catch Pancreatic Cancer Early

                Blood Test May Help Doctors Catch Pancreatic Cancer Early

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                Mental health and brain research must be a higher priority in global response to tackle COVID-19 pandemic

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                  Unusually Clear Skies Drove Record Loss of Greenland Ice in 2019

                  Volcanic CO2 emissions helped trigger Triassic climate change

                  Volcanic CO2 emissions helped trigger Triassic climate change

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                  New Species Discovered During Exploration of Abyssal Deep-Sea Canyons off Ningaloo

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                          Blood Test May Help Doctors Catch Pancreatic Cancer Early

                          by Insciences
                          April 16, 2020
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                          Blood Test May Help Doctors Catch Pancreatic Cancer Early
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                          Penn study shows liquid biopsy may be viable option for both diagnosis and disease staging

                          PHILADELPHIA – A blood test may be able to detect the most common form of pancreatic cancer while it is still in its early stages while also helping doctors accurately stage a patient’s disease and guide them to the appropriate treatment. A multidisciplinary study from the University of Pennsylvania found the test – known as a liquid biopsy – was more accurate at detecting disease in a blinded study than any other known biomarker alone, and was also more accurate at staging disease than imaging is capable of alone. The team, which includes researchers from the Perelman School of Medicine, the Abramson Cancer Center, and the School of Engineering and Applied Science, published their findings today in Clinical Cancer Research, a journal of the American Association for Cancer Research.

                          Pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer, is the third leading cause of cancer deaths. The overall five-year survival rate is just nine percent, and most patients live less than one year following their diagnosis. One of the biggest challenges is catching the disease before it has progressed or spread. If the disease is caught early, patients may be candidates for surgery to remove the cancer, which can be curative. For locally advanced patients – meaning patients whose cancer has not spread beyond the pancreas but who are not candidates for surgery based on the size or location of the tumor – treatment involves three months of systemic therapy like chemo or radiation, then reassessing to see if surgery is an option. For patients whose disease has spread, there are currently no curative treatment options.

                          “Right now, the majority of patients who are diagnosed already have metastatic disease, so there is a critical need for a test that can not only detect the disease earlier but also accurately tell us who might be at a point where we can direct them to a potentially curative treatment,” said the study’s co-senior author Erica L. Carpenter, MBA, PhD, director of the Liquid Biopsy Laboratory and a research assistant professor of Medicine. The study’s other co-senior author is David Issadore, PhD, an associate professor of Bioengineering and Electrical and Systems Engineering.

                          Researchers in this study developed a blood test to screen for a panel of biomarkers instead of just one biomarker on its own. These markers include carbohydrate antigen 19-9 (CA19-9) and KRAS mutational burden, which are known to be associated with PDAC. In a blinded test group of 47 patients (20 with PDAC, 27 who were cancer free), the test was 92 percent accurate in its ability to detect disease, which outperforms the best known biomarker, CA19-9 (89 percent), alone.

                          The researchers then used samples from the 25 patients who imaging showed did not have metastatic disease. The Penn test was 84 percent accurate in determining disease staging, which is significantly higher than imaging alone (64 percent).

                          While the test still needs to be validated in a larger cohort, researchers say they are excited by the promise of what it could potentially mean for a patient population in need of this kind of advancement.

                          “If validated, this test could not only provide a key tool for at-risk patients, but also a monitoring tool for patients with certain known risk factors like BRCA mutations,” Carpenter said.

                          The researchers also note this work would not have been possible without cooperation and coordination across multiple disciplines at Penn, including Hematology-Oncology, Radiation Oncology, Pathology and Laboratory Medicine, Mechanical Engineering and Applied Mechanics, Bioengineering, Surgery, and more. The study also received critical financial support from the Pancreatic Cancer Action Network, the University of Pennsylvania Pancreatic Cancer Research Center, and the Abramson Cancer Center Pancreatic Translational Center of Excellence.

                          The study’s first author is Zijian Yang, a PhD student at the University of Pennsylvania. Additional Penn authors include Michael J. LaRiviere, Jina Ko, Jacob E. Till, Theresa E. Christensen, Stephanie S. Yee, Taylor A. Black, Kyle Tien , Andrew Lin, Hanfei Shen, Neha Bhagwat, Daniel Herman, Andrew Adallah, Mark H. O’Hara, Charles M. Vollmer, Bryson W. Katona, and Ben Z. Stanger.

                          Additional support for this study came from the Pennsylvania Department of Health, the National Institutes of Health (R21MH118170), the American Cancer Society (RSG-15-227-01-CSM), and Congressionally Directed Medical Research Programs (W81XWH-19-2-0002).

                          Source: Penn Medicine – University of Pennsylvania

                          Tags: BiomakersBlood testliquid biopsyPancreatic CancerPancreatic ductal adenocarcinomaPDAC
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