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p53 News (37 articles)



Single gene defect wipes out immunity

Gene knockout stops immune cell development.Researchers at the Wellcome Trust Sanger Institute have identified the key gene in ensuring that our immune defences develop infection-fighting cells. No cells of the adaptive immune system - key to attacking and destroying bacteria and...

Published on 10 December 2012, 09:51


Comprehensive genomic analysis sheds new light on subtypes of breast cancer

HOUSTON -- (September 24, 2012) -- Comprehensive genomic analysis of breast tumors revealed four main subclasses of breast cancer, each of which has extensive genetic heterogeneity, said an international consortium of scientists in The Cancer Genome Atlas Network that included those from...

Published on 24 September 2012, 10:23


Research Shows Gene Defect's Role in Autism-Like Behavior

(SACRAMENTO, Calif.) — Scientists affiliated with the UC Davis MIND Institute have discovered how a defective gene causes brain changes that lead to the atypical social behavior characteristic of autism. The research offers a potential target for drugs to treat the...

Published on 11 August 2012, 12:41


Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor

St. Jude Children’s Research Hospital scientists discovered that the protein TopBP1 is indispensible for preventing the accumulation of DNA damage early in brain formation and might also serve as a tumor suppressor.Memphis, Tennessee-- St. Jude Children’s Research Hospital scientists have...

Published on 24 April 2012, 03:49


Sending out an SOS: How telomeres incriminate cells that can't divide

Salk scientists' discovery explains how a class of chemotherapy drugs works.LA JOLLA, CA—The well-being of living cells requires specialized squads of proteins that maintain order. Degraders chew up worn-out proteins, recyclers wrap up damaged organelles, and-most importantly-DNA repair...

Published on 12 March 2012, 10:02


Rigged to explode? Inherited mutation links exploding chromosomes to cancer

An inherited mutation in a gene known as the guardian of the genome is likely the link between exploding chromosomes and some particularly aggressive types of cancer, scientists at the European Molecular Biology Laboratory (EMBL), the German Cancer Research Centre (DKFZ) and the University...

Published on 19 January 2012, 14:20


New anti-inflammatory drugs might help avoid side effects of steroids

Salk scientists discover that a cancer-suppressing protein might serve as a target for a new type of anti-inflammatory drug.LA JOLLA, CA—A new class of anti-inflammatory drugs may one day serve as an alternative to steroid medications and possibly help avoid the serious side effects of...

Published on 25 October 2011, 09:17


New Lung Cancer Gene Found

Cancer biologists identify a driving force behind the spread of an aggressive type of lung cancer.CAMBRIDGE, Mass. -- A major challenge for cancer biologists is figuring out which among the hundreds of genetic mutations found in a cancer cell are most important for driving the cancer’s...

Published on 19 July 2011, 15:50


Understanding Why Lung Cancer Spreads

MIT biologists pinpoint a genetic change that helps tumors move to other parts of the body. CAMBRIDGE, Mass. — MIT cancer biologists have identified a genetic change that makes lung tumors more likely to spread to other parts of the body. The findings, published in the April 6 online issue...

Published on 7 April 2011, 05:20


U of Alberta researcher discovers potential cancer therapy target

A University of Alberta researcher in the Faculty of Medicine & Dentistry may have found a new target for cancer therapy.One of the most important genes in the human genome is called p53 and its function is to suppress tumours, says Roger Leng, a researcher in the Department of Laboratory...

Published on 14 February 2011, 17:27


Protein Disables p53, Drives Breast Cells Toward Cancer Transition

High expression of TRIM24 is common in breast cancer, correlates with poor survival.The recently identified TRIM24 protein plays an active role in pushing normal breast cells into rapid cell proliferation and, potentially, into breast cancer.Reporting in the journal Nature, a team led by...

Published on 16 December 2010, 09:38


Biologists find that restoring the gene for cancer protein p53 slows spread of advanced tumors

CAMBRIDGE, Mass. — In a new study published in the Nov. 25 issue of Nature, MIT cancer biologists show that restoring the protein p53’s function in mice with lung cancer has no effect early in tumor development, but restoring the function later on could prevent more advanced tumors from...

Published on 25 November 2010, 05:39


A New Way of Reversing Certain Cancers

Australian and American scientists have found a way of shrinking tumours in certain cancers – a finding that provides hope for new treatments.The cancers in question are those caused by a new class of genes known as ‘microRNAs’, produced by parts of the genome that, until recently, were...

Published on 28 September 2010, 07:40


Biologists Find Way to Reduce Stem Cell Loss During Cancer Treatment

Biologists at the University of California, San Diego have discovered that a gene critical for programmed cell death is also important in the loss of adult stem cells, a finding that could help to improve the health and well-being of patients undergoing cancer treatment.“During...

Published on 8 September 2010, 05:24


Singapore Scientists Exploit Knowledge of p53 for a Novel Way of Increasing Specificity of Cancer Treatments

Healthy cells need not be destroyed during cancer treatment.Researchers from the p53 Laboratory of Singapore’s Agency for Science, Technology and Research (A*STAR), have made a finding that makes feasible a unique method of cancer treatment. Their work, published online in the leading journal...

Published on 21 May 2010, 03:32


Cancer Breakthrough Could Save Children’s Lives

A cancer which claims the lives of thousands of children worldwide every year is a step closer to being cured thanks to a breakthrough by scientists at Newcastle University.New research, published in the current edition of the American publication Clinical Cancer Research, could offer hope to...

Published on 17 February 2010, 04:28


Loss of Guardian Angel Gene Triggers Premature Birth, A Major Cause of Neonatal Death, Long-Term Disability

Mutation of a gene that helps protect the body from genetic instability leads to cellular and molecular changes in the pregnant uterus that trigger premature birth, according to a study appearing online Feb. 1 in the Journal of Clinical Investigation. The research by scientists in the Division of...

Published on 4 February 2010, 04:34


How Cells Tolerate DNA Damage – MDC Researchers Identify Start Signal for Cell Survival Program

Cancer researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch have gained new insights into how cells react to DNA damage. Dr. Michael Stilmann, Dr. Michael Hinz and Professor Claus Scheidereit have shown that the protein PARP-1, which detects DNA damage within seconds,...

Published on 16 November 2009, 06:23


McGill researchers identify key genetic factors which can lead to cancer

Newly understood relationship between genes could lead to more successful "personalized" treatmentsResearchers at McGill University have discovered a previously unknown series of interactions between genes that control whether cells become cancerous. The discovery may lead to a new generation of...

Published on 3 November 2009, 15:43


Trigger of deadly food toxin discovered

Finding by UCI scientists could help prevent cancer.A toxin produced by mold on nuts and grains can cause liver cancer if consumed in large quantities. UC Irvine researchers for the first time have discovered what triggers the toxin to form, which could lead to methods of limiting its...

Published on 21 October 2009, 14:17


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