Breast Cancer News (153 articles)

(SACRAMENTO, Calif.) — A key step in understanding the origins of familial breast cancer has been made by two teams of scientists at the University of California, Davis. The researchers have purified, for the first time, the protein produced by the breast cancer susceptibility gene BRCA2 and...

Published on 23 August 2010, 11:09

Categories: BRCA2 Breast Cancer DNA Repair DSS1

(Boston) - Investigators from the Slone Epidemiology Center at Boston University School of Medicine (BUSM) have reported that African American women who use oral contraceptives have a greater likelihood of developing breast cancer than nonusers. The study results, recently published on-line...

Published on 3 August 2010, 08:44

Categories: Breast cancer Contraceptives Oral contraceptives

Researchers from Brown University and the University of California have shown that the epigenetic profiles of breast tumors are related to patient diet and alcohol use as well as tumor size. PROVIDENCE, R.I. [Brown University] — Researchers from Brown University and the University...

Published on 2 August 2010, 06:51

Categories: Alcohol Biomarkers Breast Cancer Breast tumors Diet Epigenetics

UA researchers participated in the discovery of an unexpected role played by a protein molecule, making it a candidate for a biomarker or drug target for breast cancer.University of Arizona researchers are part of an international team that has discovered a new cellular mechanism that is...

Published on 13 July 2010, 12:24

Categories: Breast Cancer Cancer NF-kB Proteins Rap1

Australian researchers have uncovered a new mutation in stem cells that may be linked to the development of leukaemia, breast and colon cancer.A team led by Dr Peter Papathanasiou from The John Curtin School of Medical Research at The Australian National University and Associate Professor Andrew...

Published on 8 July 2010, 07:12

Categories: Stem Cells Cancer Leukemia Breast Cancer Colon Cancer c-Myb Blood Stem cells

T-DM1 is the first antibody-drug conjugate in Roche’s pipeline to be submitted to the FDA.Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the company submitted a Biologics Licence Application (BLA) to the U.S. Food and Drug Administration (FDA) for trastuzumab-DM1 (T-DM1) in people with...

Published on 7 July 2010, 05:33

Categories: Trastuzumab-DM1 T-DM1 advanced HER2-positive breast cancer Breast Cancer HER2 Trastuzumab Chemotherapy DM1 TDM4374g

New Strategy Holds Promise for Fewer Patient Side Effects.PHILADELPHIA – A novel therapy designed to attack tumors in patients with a genetic mutation in either BRCA1 or BRCA2, slowed tumor growth in 85 percent of advanced breast cancer patients treated in a small study, researchers report...

Published on 6 July 2010, 10:50

Categories: BRCA1 BRCA2 Breast Cancer Olaparib PARP Poly (ADP-ribose) polymerase Tumor Growth

Scientists at the Genome Institute of Singapore (GIS), a biomedical research institute of the Agency for Science, Technology and Research (A*STAR), and the Karolinska Institutet, Sweden, recently discovered that DNA polymorphisms related to the production of estrogen play an important role in the...

Published on 2 July 2010, 11:08

Categories: Breast Cancer DNA polymorphisms Endometrial Cancer Estrogen Estrogen metabolism Nucleotide polymorphisms SNPs

Women who drink boiled coffee more than four times a day run a lower risk of developing breast cancer than women who drink coffee less than once a day. This is shown by Lena Nilsson and her associates at Umeå University in an article in the journal Cancer Causes & Control.A major difference...

Published on 15 June 2010, 04:27

Categories: Breast Cancer Coffee Boiled Coffee Filtered Coffee Coffee consumption

New Haven, Conn. — In a study that sheds light on why breast cancer may be deadlier for premenopausal women, a Yale School of Medicine team has linked breast cancer survival with levels of a transport protein that regulates milk production in mammary glands. The paper is published in the online...

Published on 31 May 2010, 14:48

Categories: Breastfeeding Breast Cancer Breast Milk Plasma membrane calcium-ATPase 2 PMCA2

New Haven, Conn. — Exposure in the womb to chemicals like Bisphenol-A (BPA) and Diethylstilbestrol (DES) can increase an offspring’s risk of breast cancer, researchers at Yale School of Medicine report in a study published in current issue of Hormones and Cancer, a journal of The Endocrine...

Published on 28 May 2010, 12:10

Categories: Bisphenol A Chemicals BPA Diethylstilbestrol DES Breast Cancer Estrogen Cancer Hormones

New trials harness immune system to improve efficacy of therapeutic vaccine, chemotherapy.CHICAGO – Early trials using targeted monoclonal antibodies in combination with existing therapies show promise in treating pancreatic cancer and metastatic breast cancer, according to research that will...

Published on 28 May 2010, 05:55

Categories: Pancreatic Cancer Breast Cancer nti-CD25 mAb dacluzimab Tregs CD40 agonist monoclonal antibody CP-870 893

Penn Studies Reveal Patterns in Reasons Women Struggle to Remain on Lifesaving Therapy, Points to Personalized Strategies to Boost Compliance.CHICAGO — Aromatase inhibitor-associated arthralgia (AIAA)  is a major side effect in breast cancer survivors, producing joint pain so severe that...

Published on 28 May 2010, 05:42

Categories: Joint Pain Breast Cancer Drugs Breast Cancer Drugs Aromatase inhibitor-associated arthralgia AIAA

A DNA-vaccine that restricts the supply of blood to tumours has been developed by scientists at the Karolinska Institutet. The vaccine slows the growth of breast cancer tumours in mice.If a cancer tumour is to become larger than a few millimetres it must be able to stimulate the formation of new...

Published on 24 May 2010, 10:35

Categories: Vaccines Cancer Vaccine Blood Breast Cancer Delta-like ligand 4 DLL4 DNA vaccine

Scientists have identified a group of surface markers on cells linked to an aggressive type of breast cancer called estrogen receptor-negative cancer. In this preliminary study, estrogen-negative breast cancer developed when three markers, CD44+, CD49fhi, and CD133hi were present simultaneously...

Published on 18 May 2010, 12:50

Categories: Breast Cancer CD133hi CD44+ CD49fhi Estrogen-negative breast cancer Xenograft-initiating cells XIC

Scientists have found five new regions of the genome that increase a woman’s risk of developing breast cancer by between six and 16 per cent, according to a study in Nature Genetics (Sunday)*.The results of the study, funded by Cancer Research UK and the Wellcome Trust and carried out by...

Published on 11 May 2010, 01:56

Categories: Breast Cancer CDK2NA Cell Division Genetics Genome Melanoma

Washington, DC – A study by researchers from the Georgetown Lombardi Comprehensive Cancer Center at Georgetown University Medical Center (GUMC) identifies a potential new combination therapy to “rescue” treatment sensitivity to fulvestrant in estrogen receptor positive breast cancers. The...

Published on 10 May 2010, 12:43

Categories: IFNγ Fulvestrant Breast Cancer Estrogen IRF1 NF- κB BCL-2 ER+ Breast Cancer Estrogen receptor

Mayo Clinic study calls for early detection among obese women.Scottsdale, Ariz. — Obese women may be at risk for having breast cancer detected at a later stage and may have lower overall survival rates than non-obese women, according to a Mayo Clinic study presented at the 2010 American Society...

Published on 7 May 2010, 04:28

Categories: Breast Cancer Breast Cancer detection Obese Women Obesity

Research in mice, cells suggests possible prevention, treatment strategy.ANN ARBOR, Mich. — A compound derived from broccoli could help prevent or treat breast cancer by targeting cancer stem cells -- the small number of cells that fuel a tumor’s growth -- according to a new study from...

Published on 3 May 2010, 13:28

Categories: Breast Cancer Breast Cancer Stem Cells Broccoli Broccoli sprouts Cancer Stem Cells Sulforaphane

New Haven, Conn. — Scientists for the first time have discovered a way to predict whether women with the most common form of non-invasive breast cancer — ductal carcinoma in situ (DCIS)— are at risk of developing more invasive tumors in later life. The study appears online in The Journal of...

Published on 2 May 2010, 06:31

Categories: Breast Cancer Ductal carcinoma in situ DCIS Mastectomy Radiation