Keyword Tag Sort by


Categories: Omega-3 Omega 3 fatty acids Cancer DHA Cytostatics Neural Cancer Neuroblastoma hydroperoxy fatty acids Docosahexaenoic acid

Omega-3 Possible Weapon Against Neural Tumours in Children

In a newly published study, Swedish and American scientists show how the Omega-3 fatty acid DHA can serve as both sword and shield in the fight against certain forms of cancer. The new findings on the mechanisms behind this two-sided effect give hope of one day using DHA as a complement to cytostatics in the treatment of children with neural cancer.

Neural cancer (neuroblastoma) in young children is the most common solid tumour form in this age group. The prognosis is very poor and some 40 per cent of patients die of the disease. However, it is known that fatty acids can protect healthy nerve cells from dying, and at the same time kill several types of cancer cells. In the current study, the scientists were interested in exploring what happens to DHA, an Omega-3 fatty acid found mainly in oily fish (e.g. salmon and mackerel), inside the cancer cell.

Using an advanced method called liquid chromatography combined with mass spectrometry, the researchers looked at the products that were formed on the breakdown of DHA and which of them have a lethal effect on the cancer cell. They also tried to identify the enzymes involved in the breakdown process.

"We observed that DHA forms hydroperoxy fatty acids and hydroxy fatty acids inside the cancer cell," says Helena Gleissman, researcher at Karolinska Institutet and the study´s principal author. "These fatty acids are oxidised through the agency of enzymes called 5- and 15-lipoxygenase, but they can also be oxidised spontaneously. Hydroperoxy fatty acids are particularly involved in apoptosis."

DHA can be converted into these cell-killing oxidised fatty acids in healthy neurons, but they are then converted further into substances called resolvins and protectins, thus avoiding the accumulation of cytolethal oxidised fatty acids in the cell. Protectins are particularly effective at protecting nerve cells from dying, which from a future treatment perspective makes it especially interesting that neither resolvins nor protectins are formed in neuroblastoma cells.

"While DHA kills cancer cells in the nervous system via hydroperoxy fatty acids, it protects healthy nerve cells from dying via protectins," says Dr Gleissman. "If we can find a way of controlling this process, there is a good chance that DHA can serve as both sword and shield in neuroblastoma patients and act as a complement to cytostatic therapy."

The study was based on a collaboration between Professor Per Kogner´s research group at Karolinska Institutet and Professor Charles N Serhan´s group at Harvard Medical School. The researchers will now be looking into how DHA can be applied most effectively in the treatment of cancer. The research was funded by the Swedish Children´s Cancer Foundation, Swedish Research Council, Swedish Cancer Society, Erik and Edith Fernström´s Foundation for Medical Research, Cystic Fibrosis Foundation, and NIH.

Publication:
Helena Gleissman, Rong Yang, Kimberly Martinod, Magnus Lindskog, Charles N. Serhan, John Inge Johnsen & Per Kogner
Docosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates
The FASEB Journal, print issue March 2010.
Abstract

Contact: Press Office,  Phone: +46(0)8-524 860 77, E-mail: pressinfo@ki.se

Source: Karolinska Institutet

Photos (2)  [ view all photos ]


Helena Gleissman Photo: Anna Rehnberg


By knipseline. Pixelio

Related News:

Protein that accelerates age, brakes cancer 11 August 2013, 12:57
Prelamin A protein causes accelerated ageing disorders and also prevents the spread of cancer...

Study IDs key protein for cell death 16 May 2013, 04:32
Findings may offer a new way to kill cancer cells by forcing them into an alternative...

Mapping of cancer cell fuel pumps paves the way for new drugs 29 April 2013, 03:26
For the first time, researchers at Karolinska Institutet have managed to obtain detailed images...

Understanding Abnormal Proteins in Degenerative Diseases 22 April 2013, 07:55
New IBN Peptides May Help Researchers Combat Alzheimer’s, Diabetes and...

Omega-3 can help laying hens avoid bone damage 28 January 2013, 08:47
Most of us are aware of the potential health benefits of omega-3 found in fish oil and flax...

A*STAR Scientists Identify Potential Drug Target For Inflammatory... 21 November 2012, 03:24
This discovery holds the potential to reduce healthcare costs for many common inflammatory...

Gene switch important in cancer discovered 2 November 2012, 03:10
Scientists at Karolinska Institutet in Sweden and the University of Helsinki in Finland have...

Obesity Promotes Tumor Growth Regardless of Diet 15 October 2012, 03:37
Presence of fat tissue-derived cells in tumors is related to increased tumor growth. The...

How Cancer Cells Break Free From Tumors 11 October 2012, 04:02
New MIT study identifies adhesion molecules key to cancer’s spread through the body.CAMBRIDGE,...

Reining in Metastatic Cells 9 October 2012, 14:22
Most cancer deaths are caused by metastases, secondary tumors seeded by cells that escape from...

Credits / Source:

Helena Gleissman Photo: Anna Rehnberg


By knipseline. Pixelio