Keyword Tag Sort by


Categories: Nanotechnology Burns Infection Inflammation Second-degree burns Nanoemulsion lotion Nanoemulsion

Nanotechnology treatment for burns reduces infection, inflammation

Oil-and-water-based nanoemulsion could be more effective than commonly used lotions.

ANN ARBOR, Mich.---Treating second-degree burns with a nanoemulsion lotion sharply curbs bacterial growth and reduces inflammation that otherwise can jeopardize recovery, University of Michigan scientists have shown in initial laboratory studies.

U-M burn surgeon Mark R. Hemmila, M.D., reports today at the Interscience Conference for Antimicrobial Agents and Chemotherapy on results achieved with a nanoemulsion developed at U-M and licensed by U-M to Ann Arbor-based NanoBio Corporation.

The nanoemulsion shows promise in overcoming the limitations of current creams used in burn treatment, which aren’t able to penetrate skin to kill sub-surface bacteria and don’t have a strong effect on inflammation, says Hemmila, associate professor of surgery at the U-M Medical School.

In a collaborative effort between the U-M Department of Surgery and NanoBio Corporation, Hemmila led experiments at the U-M Medical School in which a nanoemulsion lotion was able to reduce bacterial growth one-thousand-fold compared to control animals receiving no treatment or a placebo. The nanoemulsion showed a similar reduction when compared to a topical antimicrobial agent commonly used in people with burns.

The nanoemulsion is made of soybean oil, alcohol, water and detergents emulsified into droplets less than 400 nanometers in diameter. It has proved effective at killing a variety of bacteria, fungi and viruses in previous research.

The scientists used the nanoemulsion to treat partial thickness burns, better known as second degree burns, over 20 percent of the body, to test its effectiveness in the type of injuries doctors commonly see in people brought to tertiary hospital trauma and burn centers. Such burn victims typically require aggressive treatment in intensive care both to rein in infection and to try to prevent vital fluids from leaking from blood vessels into the damaged skin, a dangerous situation caused in part by excessive inflammation within the body.

The nanoemulsion appears to reduce the action of two inflammatory agents or cytokines that play a role in cell signaling during this critical post-burn period. Slowing this action may prevent initial burn damage from becoming worse, and thus reduce the severity of the burn and extent of skin grafting needed, says Hemmila.

The findings add one more possible use to a growing list of promising applications for the patented nanoemulsion technology developed by James R. Baker Jr., M.D., director of the Michigan Nanotechnology Institute for Medicine and Biological Sciences at U-M. Baker, a member of the research team, is the Ruth Dow Doan Professor of Nanotechnology and allergy division chief at the U-M Medical School. He is founder and CEO of NanoBio Corporation.

Uses for nanoemulsions include treatments for cold sores, now in phase 3 clinical trials, and for toenail fungus and cystic fibrosis infections, as well as vaccines against influenza and bioterrorism agents.

Before the burn treatment can be tested in people, further laboratory studies are needed to examine the nanoemulsion’s effects on the overall healing process.

Patents/Disclosures: The patented nanoemulsion technology is licensed by U-M to NanoBio Corporation. Baker holds an equity interest in the company.

Others involved in the research: Stewart C. Wang, M.D., Ph.D., director of the U-M Burn Center and professor, U-M Department of Surgery; Aladdein Mattar, M.D., U-M Department of Surgery; Michael A. Taddonio, B.S., U-M Department of Surgery; Joyce A. Sutcliffe, Ph.D., NanoBio Corporation.

Funding: National Institutes of Health, American Association for the Surgery of Trauma, American College of Surgeons, and U-M Department of Surgery.

Contact: Anne Rueter, E-mail: arueter@umich.edu, Phone: 734-764-2220

Source: University of Michigan Health System

Related News:

Light nanofilter system worth its weight in gold and silver 28 October 2013, 04:37
In a breakthrough described by one international expert as ‘a wonderful piece of lateral...

A*STAR Scientists Identify Potential Drug Target For Inflammatory... 21 November 2012, 03:24
This discovery holds the potential to reduce healthcare costs for many common inflammatory...

New Gene Test Flags Risk of Serious Complications in Sarcoidosis 12 October 2012, 04:22
Researchers at the University of Illinois Hospital & Health Sciences System have identified...

Discovery may lead to new drugs to curb obesity, type 2 diabetes 11 October 2012, 03:47
An international study led by a researcher from The University of Western Australia for the...

Researchers unravel the secret to making cheap, high-density data... 10 October 2012, 03:46
Imagine being able to store thousands of songs and high-resolution images on data devices no...

Graphene membranes may lead to enhanced natural gas production,... 8 October 2012, 13:34
Engineering faculty and students at the University of Colorado Boulder have produced the first...

More Efficient All-Organic Catalysts in Fuel Cells 5 October 2012, 04:54
Organic catalysts are a breakthrough in the quest for inexpensive and efficient materials for...

Zinc deficiency mechanism linked to aging, multiple diseases 2 October 2012, 08:03
CORVALLIS, Ore. – A new study has outlined for the first time a biological mechanism by which...

Nano-Velcro Clasps Heavy Metal Molecules in its Grips 10 September 2012, 03:45
10.09.12 - Researchers develop nano-strips for inexpensive testing of mercury levels in our...

Researchers Use First-of-Its-Kind Approach to Design Nanomedicines... 10 July 2012, 14:19
BOSTON, MA—Researchers at Brigham and Women's Hospital (BWH) are the first to report a...