Keyword Tag Sort by


Categories: Magnetic Resonance Imaging MRI Oncology Oxygen Tumors

Oxygen + MRI might help determine cancer therapy success

DALLAS — June 3, 2009 — A simple magnetic resonance imaging (MRI) test involving breathing oxygen might help oncologists determine the best treatment for some cancer patients, report researchers at UT Southwestern Medical Center.

Prior research has shown that the amount of oxygen present in a tumor can be a predictor of how well a patient will respond to treatment. Tumors with little oxygen tend to grow stronger and resist both radiotherapy and chemotherapy. Until now, however, the only way to gauge the oxygen level in a tumor, and thus determine which treatment might be more effective, was to insert a huge needle directly into the cancerous tumor.

The new technique, known as BOLD (blood oxygen level dependent) MRI, can detect oxygen levels in tumors without the need for an invasive procedure. The patient need only be able to breathe in oxygen when undergoing an MRI.  

  mason_low resi
  Drs. Ralph Mason (left) and Dawen Zhao, both radiologists, have demonstrated that blood oxygen level dependent MRIs might help oncologists determine the best treatment for some cancer patients.
 

“The patient simply inhales pure oxygen, which then circulates through the bloodstream, including to the tumors,” said Dr. Ralph Mason, professor of radiology, director of the UT Southwestern Cancer Imaging Center and senior author of a study appearing online and in a future edition of Magnetic Resonance in Medicine. “Using MRI, we can then go in and estimate how much oxygen a particular tumor is taking up, providing us some insight into how the tumor is behaving and what sort of treatment might be effective.”

The most important finding, Dr. Mason said, is that BOLD MRI performed as well as the standard yet more invasive procedure for viewing tumors. That method, known as FREDOM (fluorocarbon relaxometry using echo planar imaging for dynamic oxygen mapping) MRI, requires the injection of a chemical called a reporter molecule directly into the tumor.

“The BOLD technique appears to indicate accurately the oxygen levels in tumors,” Dr. Mason said. “Because BOLD is immediately applicable to patients, this holds promise as a new method for predicting response to therapy.”

BOLD MRI has been used extensively in studying brain function, but the procedure has only recently begun to be used to assess blood oxygenation and vascular function in tumors.

Physicians at UT Southwestern are already testing BOLD MRI in patients with cervical, prostate, and head and neck cancer. They have proposed using it in lung cancer patients as well, Dr. Mason said. Previous research has shown that those specific tumor types are more likely to have little oxygen.

In the published study, researchers took multiple images of breast tumors implanted just below the skin of rats, which were given anesthesia to help them remain still during the imaging process. Humans do not require anesthesia, Dr. Mason said.

Dr. Mason said the team took the research back to the preclinical stage because they needed to better define what physicians were seeing in the clinic and whether the findings were reproducible.

Dr. Mason said that examining each form of cancer in this way presents its own technical challenges. For example, the motion of the lungs or the design of a face mask for breathing oxygen must be taken into account.

“If we can prove that the test is meaningful in animals, then it is that much more worthwhile to argue for doing it in a patient. This preclinical work provides the foundation for future clinical studies,” Dr. Mason said. “It helps justify doing a larger clinical trial with the goal of ultimately becoming a diagnostic test for oncologists.”

Researchers currently are trying to determine how much oxygen must be inhaled by a patient in order to be effective. The next step is to expand studies in patients and prove the relevance to more tumor types.

Other UT Southwestern researchers involved in the research were Dr. Dawen Zhao, lead author and assistant professor of radiology; Dr. Lan Jiang, a postdoctoral researcher in radiation oncology; and Dr. Eric Hahn, consultant in radiology.

The work was supported by the Department of Defense and the National Cancer Institute. The MRI experiments were performed in UT Southwestern’s Advanced Imaging Research Center, an NIH-funded basic and translational research facility.

Visit http://www.utsouthwestern.org/radiology to learn more about UT Southwestern’s clinical services in radiology, including oncology imaging. Visit http://www.utsouthwestern.org/cancercenter to learn more about clinical services in cancer at UT Southwestern.


Contact: Kristen Holland Shear, 214-648-3404, kristen.hollandshear@utsouthwestern.edu

Related News:

Burkitt Lymphoma Survival Improves For Some 11 August 2013, 13:15
Treatment advances have helped improve patient survival of Burkitt lymphoma, a highly aggressive...

Breast Cancer Drug Could Halt Other Tumours 7 November 2012, 06:03
A drug commonly used in treating breast cancer could have far wider benefits, offering a new way...

Reining in Metastatic Cells 9 October 2012, 14:22
Most cancer deaths are caused by metastases, secondary tumors seeded by cells that escape from...

Journal of Clinical Oncology Publishes Phase III Results of... 8 October 2012, 04:55
Paris, France – October 8, 2012 – Sanofi (EURONEXT: SAN and NYSE: SNY) today announced that...

More Efficient All-Organic Catalysts in Fuel Cells 5 October 2012, 04:54
Organic catalysts are a breakthrough in the quest for inexpensive and efficient materials for...

Blocking Tumor-Induced Inflammation Impacts Cancer Development 3 October 2012, 13:40
How tumors exploit microflora and immune cells to fuel growth.Researchers at the University of...

Making cell division impossible: Optimized substance forces cancer... 1 October 2012, 14:06
Many tumor cells have a defective cellular equipment. It is only by a special trick that they...

Study Shows Brain Function Differences in Women with Anorexia 17 September 2012, 05:28
A new study published in Social Cognitive and Affective Neuroscience by researchers at the Center...

All Cancer Cells Are Not Created Equal 16 May 2012, 12:21
Some cell types control continued tumor growth, others prepare the way for metastasis.A study...

Cutting off the oxygen supply to serious diseases 30 January 2012, 07:15
A new family of proteins which regulate the human body’s ‘hypoxic response’ to low levels...