Strict Standards: Non-static method SEBenchmark::getInstance() should not be called statically in /home3/nextron/public_html/header.php on line 35

Strict Standards: Non-static method SESmarty::getInstance() should not be called statically in /home3/nextron/public_html/header.php on line 43

Strict Standards: Non-static method SEDatabase::getInstance() should not be called statically in /home3/nextron/public_html/header.php on line 96

Strict Standards: Non-static method SELanguage::info() should not be called statically in /home3/nextron/public_html/header.php on line 104

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 334

Strict Standards: Non-static method SELanguageStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/language.php on line 156

Strict Standards: Declaration of SELanguageStorageMysql::edit() should be compatible with SELanguageStorage::edit() in /home3/nextron/public_html/include/language/storage/mysql.php on line 255

Strict Standards: Declaration of SELanguageStorageMysql::get() should be compatible with SELanguageStorage::get() in /home3/nextron/public_html/include/language/storage/mysql.php on line 255

Strict Standards: Non-static method SECore::getSettings() should not be called statically in /home3/nextron/public_html/header.php on line 107

Strict Standards: Non-static method SECache::getInstance() should not be called statically in /home3/nextron/public_html/include/class_core.php on line 28

Strict Standards: Non-static method SECacheStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/cache/cache.php on line 66

Strict Standards: Non-static method SEDatabase::getInstance() should not be called statically in /home3/nextron/public_html/include/class_core.php on line 39

Strict Standards: Non-static method SECache::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_url.php on line 67

Strict Standards: Non-static method SECacheStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/cache/cache.php on line 66

Strict Standards: Non-static method SEDatabase::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_url.php on line 78

Strict Standards: Non-static method SELanguage::_preload_multi() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_datetime.php on line 35

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/language.php on line 529

Strict Standards: Non-static method SESession::getInstance() should not be called statically in /home3/nextron/public_html/header.php on line 125

Strict Standards: Non-static method SESessionStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/session/session.php on line 49

Strict Standards: Declaration of SESessionStorageNone::register() should be compatible with SESessionStorage::register($options = Array) in /home3/nextron/public_html/include/session/storage/none.php on line 16

Strict Standards: Non-static method SEDatabase::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/session/session.php on line 600

Strict Standards: Non-static method SESession::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_user.php on line 509

Strict Standards: Non-static method SESession::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_admin.php on line 208

Strict Standards: Non-static method SELanguage::select() should not be called statically in /home3/nextron/public_html/header.php on line 181

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 234

Strict Standards: Non-static method SELanguage::info() should not be called statically in /home3/nextron/public_html/header.php on line 183

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 334

Strict Standards: Non-static method SELanguage::info() should not be called statically in /home3/nextron/public_html/header.php on line 189

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 334

Strict Standards: Non-static method SECore::getPlugins() should not be called statically in /home3/nextron/public_html/header.php on line 229

Strict Standards: Non-static method SECache::getInstance() should not be called statically in /home3/nextron/public_html/include/class_core.php on line 62

Strict Standards: Non-static method SECacheStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/cache/cache.php on line 66

Strict Standards: Non-static method SEDatabase::getInstance() should not be called statically in /home3/nextron/public_html/include/class_core.php on line 73

Strict Standards: Declaration of rc_rssfeed::delete() should be compatible with rc_model::delete($id = NULL) in /home3/nextron/public_html/include/class_rssfeed.php on line 132

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 720

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 1087

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 1595

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 1636

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 1656

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 1756

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 1960

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2358

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2362

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2366

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2370

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2418

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2440

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2445

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2449

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2453

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2501

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2523

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2927

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2935

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2943

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2951

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2959

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3300

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3304

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3308

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3312

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3373

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3395

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3434

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3456

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3461

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3465

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3469

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3473

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3783

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3815

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3845

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3868

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3879

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3889

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3911

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3925

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3952

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3978

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4167

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4180

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4201

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4214

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4242

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4256

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4278

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4292

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4496

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4532

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4568

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4594

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4623

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4637

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4668

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4698

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4851

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4876

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4908

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4934

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4988

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5117

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5153

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5186

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5217

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5321

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5353

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5392

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5428

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5463

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5498

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5505

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5790

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5794

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5798

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5802

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5850

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5872

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5877

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5881

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5885

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5933

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5955

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 6392

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 7588

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 7649

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 7730

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 12921

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 12986

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 13011

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 13574

Strict Standards: Non-static method SELanguage::_preload_multi() should not be called statically in /home3/nextron/public_html/header_rssfeed.php on line 10

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 529

Strict Standards: Non-static method rc_toolkit::get_setting() should not be called statically in /home3/nextron/public_html/header_rssfeed.php on line 14

Strict Standards: Non-static method rc_toolkit::owner_level() should not be called statically in /home3/nextron/public_html/header_rssfeed.php on line 25

Strict Standards: Non-static method SELanguage::_preload_multi() should not be called statically in /home3/nextron/public_html/header_article.php on line 10

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 529

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_article.php on line 66

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_article.php on line 67

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SELanguage::_preload() should not be called statically in /home3/nextron/public_html/header_event.php on line 15

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 559

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_event.php on line 67

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_event.php on line 69

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_event.php on line 71

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_event.php on line 73

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_event.php on line 75

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SELanguage::_preload() should not be called statically in /home3/nextron/public_html/header_group.php on line 14

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 559

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_group.php on line 82

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_group.php on line 85

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_group.php on line 88

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SELanguage::_preload() should not be called statically in /home3/nextron/public_html/header_classified.php on line 15

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 559

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_classified.php on line 64

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_classified.php on line 66

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_classified.php on line 68

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_radcodes.php on line 10

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SELanguage::_preload_multi() should not be called statically in /home3/nextron/public_html/header_vid.php on line 15

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 529

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_vid.php on line 44

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_vid.php on line 45

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SELanguage::_preload_multi() should not be called statically in /home3/nextron/public_html/header_page.php on line 11

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 529

Strict Standards: Non-static method SELanguage::_preload_multi() should not be called statically in /home3/nextron/public_html/header_gmap.php on line 10

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 529

Strict Standards: Non-static method SE_Hook::exists() should not be called statically in /home3/nextron/public_html/header.php on line 298

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 246

Strict Standards: Non-static method SECache::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_user.php on line 280

Strict Standards: Non-static method SECacheStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/cache/cache.php on line 66

Strict Standards: Non-static method SEDatabase::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_user.php on line 291

Strict Standards: Non-static method SECache::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_user.php on line 320

Strict Standards: Non-static method SECacheStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/cache/cache.php on line 66

Strict Standards: Non-static method SEDatabase::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_user.php on line 331

Strict Standards: Non-static method SECache::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_user.php on line 200

Strict Standards: Non-static method SECacheStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/cache/cache.php on line 66

Strict Standards: Non-static method SEDatabase::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_user.php on line 211

Strict Standards: Non-static method SECache::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_user.php on line 240

Strict Standards: Non-static method SECacheStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/cache/cache.php on line 66

Strict Standards: Non-static method SEDatabase::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_user.php on line 251

Strict Standards: Non-static method SELanguage::_preload() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_user.php on line 179

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/language.php on line 559

Strict Standards: Non-static method SECore::getLanguages() should not be called statically in /home3/nextron/public_html/footer.php on line 14

Strict Standards: Non-static method SECache::getInstance() should not be called statically in /home3/nextron/public_html/include/class_core.php on line 96

Strict Standards: Non-static method SECacheStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/cache/cache.php on line 66

Strict Standards: Non-static method SELanguage::_languages() should not be called statically in /home3/nextron/public_html/include/class_core.php on line 110

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 366

Strict Standards: Non-static method SE_Hook::exists() should not be called statically in /home3/nextron/public_html/footer.php on line 29

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 246

Strict Standards: Non-static method SE_Hook::exists() should not be called statically in /home3/nextron/public_html/footer.php on line 32

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 246

Strict Standards: Non-static method SE_Hook::call() should not be called statically in /home3/nextron/public_html/footer.php on line 32

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 272

Strict Standards: Non-static method SELanguage::info() should not be called statically in /home3/nextron/public_html/footer.php on line 58

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 334

Strict Standards: Non-static method SELanguage::_preload_multi() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/smarty/templates_c/%%86^861^861EA998%%article.tpl.php on line 6

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/language.php on line 529

Strict Standards: Non-static method SELanguage::load() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/smarty/templates_c/%%86^861^861EA998%%article.tpl.php on line 7

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/language.php on line 686

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/storage.php on line 192

Strict Standards: Non-static method SECache::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/storage.php on line 193

Strict Standards: Non-static method SECacheStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/cache/cache.php on line 66

Strict Standards: Only variables should be passed by reference in /home3/nextron/public_html/include/language/storage/mysql.php on line 177

Strict Standards: Non-static method SELanguage::_preload_multi() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/smarty/templates_c/%%05^053^053AB562%%header_article2.tpl.php on line 4

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/language.php on line 529

Strict Standards: Non-static method SELanguage::load() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/smarty/templates_c/%%05^053^053AB562%%header_article2.tpl.php on line 5

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/language.php on line 686

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/storage.php on line 169

Strict Standards: Non-static method SECache::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/storage.php on line 170

Strict Standards: Non-static method SECacheStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/cache/cache.php on line 66
Unusual Compound Seeks and Destroys Cancerous Tumors - <br /> <b>Strict Standards</b>: Non-static method SELanguage::_get() should not be called statically, assuming $this from incompatible context in <b>/home3/nextron/public_html/include/smarty/templates_c/%%05^053^053AB562%%header_article2.tpl.php</b> on line <b>16</b><br /> <br /> <b>Strict Standards</b>: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in <b>/home3/nextron/public_html/include/language/language.php</b> on line <b>614</b><br /> insciences
Strict Standards: Non-static method SELanguage::_preload_multi() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/smarty/templates_c/%%87^870^870F1A81%%headerx.tpl.php on line 6

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/language.php on line 529

Strict Standards: Non-static method SELanguage::load() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/smarty/templates_c/%%87^870^870F1A81%%headerx.tpl.php on line 7

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/language.php on line 686
Keyword Tag Sort by


Categories: Cancer CLR1404 Compounds Tumors

Unusual Compound Seeks and Destroys Cancerous Tumors

MADISON – Imagine a compound that can both detect and treat nearly 50 different kinds of cancerous tumors, irradiating them from the inside out.

Researchers at the University of Wisconsin-Madison need not imagine.
 
Following highly promising studies in animals, UW scientists will begin a clinical trial of this extremely unusual "seek and destroy" compound this summer.

"We call this compound a 'diapeutic,'" says Jamey Weichert, a professor of radiology at the UW School of Medicine and Public Health. "It is one of only a handful of such dual-purpose compounds known to exist."

Imaging studies in animals have shown that the unusual compound, now called CLR1404, works on at least 45 different kinds of solid tumors, including those that have spread, or metastasized, to other parts of the body.

The research shows that only cancerous tumors take up and retain CLR1404 following IV injection. And when scientists attached a therapeutic radioisotope to the compound, they saw anti-tumor activity in breast, prostate, ovarian, pancreatic, kidney, colon and certain types of brain and skin cancers.

"CLR1404 selectively localizes in malignant tumor cells and then radiates them from the inside until the tumor cells die," says Weichert. "But non-cancerous cells and tissues clear the compound, if they take it up at all."

Weichert doesn't know yet exactly how or why this happens, but he suspects it has something to do with the way normal cells change into malignant cells.

"Our hypothesis is that this compound becomes trapped in tumor cell membranes because the tumor cells can't metabolize and eliminate it," says Weichert, a member of the UW Paul P. Carbone Comprehensive Cancer Center.

Weichert and his collaborators have begun sophisticated experiments to understand the unique targeting and retention mechanisms.

Weichert brought the compound from laboratories at the University of Michigan when he came to UW in 1998. Once on the Madison campus, he quickly began working with Carbone Cancer Center investigators, including several at the McArdle Laboratory for Cancer Research. The collaborations showed that the compound could locate and eradicate tumors in rodents, restoring cancer-ridden animals to good health.

The animal imaging studies wouldn't have been possible without a special small-scale, super-high-resolution scanner that combines two technologies: CT (computed tomography) and PET (positron emission tomography). Manufactured by Siemens with much input from UW medical physicists, the scanners are now in use at approximately 100 research institutions. But UW retains the first.

"The images from this hybrid micro-CT/micro-PET scanner are phenomenal," says Weichert, who also has an appointment in the medical physics department.
 
"When we inject a live cancer-inflicted mouse with CLR1404, we can vividly see how the compound moves through the body and comes to rest in the tumor."

This tumor-seeking movement was also demonstrated by Carbone Cancer Center oncologists in a physician-sponsored trial involving patients with non-small-cell lung cancer.
 
The drug was safely administered to the volunteers, and images confirmed CLR1404's unique tumor uptake and retention capabilities. Additional PET/CT imaging studies involving lung, pancreatic and prostate cancer patients are now being planned by the university.

In 2002, Weichert formed a local company, Cellectar, to carry out additional work on the compound, including more clinical trials in humans. Cellectar, which owns the licensing rights to CLR1404, will take the drug through the Food and Drug Administration regulatory approval process. Cellectar's own trials in humans are set to begin in the second quarter of the year.

Weichert is extremely hopeful about CLR1404's clinical potential. In addition to its ability to seek and destroy hard-to-treat metastasized tumors, the compound should also be useful for determining how far the initial cancer has progressed and how well the tumor responds to treatment.
 
Contact: Public Affairs, (608) 262-6343, news@uwhealth.org

Source: UW Health University of Wisconsin-Madison

Related News:

Protein that accelerates age, brakes cancer 11 August 2013, 12:57
Prelamin A protein causes accelerated ageing disorders and also prevents the spread of cancer...

Study IDs key protein for cell death 16 May 2013, 04:32
Findings may offer a new way to kill cancer cells by forcing them into an alternative...

Mapping of cancer cell fuel pumps paves the way for new drugs 29 April 2013, 03:26
For the first time, researchers at Karolinska Institutet have managed to obtain detailed images...

Understanding Abnormal Proteins in Degenerative Diseases 22 April 2013, 07:55
New IBN Peptides May Help Researchers Combat Alzheimer’s, Diabetes and...

A*STAR Scientists Identify Potential Drug Target For Inflammatory... 21 November 2012, 03:24
This discovery holds the potential to reduce healthcare costs for many common inflammatory...

Breast Cancer Drug Could Halt Other Tumours 7 November 2012, 06:03
A drug commonly used in treating breast cancer could have far wider benefits, offering a new way...

Gene switch important in cancer discovered 2 November 2012, 03:10
Scientists at Karolinska Institutet in Sweden and the University of Helsinki in Finland have...

Obesity Promotes Tumor Growth Regardless of Diet 15 October 2012, 03:37
Presence of fat tissue-derived cells in tumors is related to increased tumor growth. The...

How Cancer Cells Break Free From Tumors 11 October 2012, 04:02
New MIT study identifies adhesion molecules key to cancer’s spread through the body.CAMBRIDGE,...

Reining in Metastatic Cells 9 October 2012, 14:22
Most cancer deaths are caused by metastases, secondary tumors seeded by cells that escape from...

Sign up for daily newsletter

Subscribe to daily Science News
(a free e-mail delivery powered by Google)

Top Categories



Strict Standards: Non-static method SELanguage::load() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/smarty/templates_c/%%47^479^479B3B2F%%insciences.tpl.php on line 4

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/language.php on line 686

image

We have launched our peer- reviewed, Open-access journal: Insciences Journal

Recently added

27.11.12
Consequential Life Cycle Assessment of Nitrogen Fertilisers Based on Biomass – a Swedish perspective

08.11.12
From Molecular Hollows to Imprinting Strategies – Mass-Sensitive Devices in Host-Guest Chemistry

26.04.12
CdSe/ZnSe Quantum-Dot Semiconductor Optical Amplifiers

23.03.12
Screen-printed Electrochemical Sensors and Biosensors for Monitoring Metal Pollutants


 
 

Strict Standards: Non-static method SELanguage::load() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/smarty/templates_c/%%76^762^76224BF7%%footerx.tpl.php on line 6

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/language.php on line 686