Keyword Tag Sort by


Categories: Blood vessel growth Breast Cancer Drugs Cancer Drugs Geldanamycin Proteins Tumors VEGFR2

Breast Cancer Drug Could Halt Other Tumours

A drug commonly used in treating breast cancer could have far wider benefits, offering a new way of preventing cancers spreading through the body, according to a University of Leeds-led study.

TThe drug, geldanamycin, is well known for attacking a protein associated with the spread of breast cancer. However, a laboratory-based study found it also degraded a different protein that triggers blood vessel growth.

Stopping unwanted blood vessel growth is a key challenge in the battle against cancer, according to Dr Sreenivasan Ponnambalam, reader in human disease biology in the University of Leeds’ Faculty of Biological Sciences.

“This is potentially very significant because tumours secrete substances that stimulate blood vessels to develop around them, forming networks that supply nutrients and provide pathways for spread around the body,” Dr Ponnambalam said. “This is one of the big problems in cancer: how can we stop the tumour growing and spreading through these blood vessel networks?”

There are already other drugs available that try to stop this growth. One type tries to attack directly the membrane protein VEGFR2, which is essential for new blood vessel growth. However, that approach carries the risk of serious side-effects because proteins in the membrane walls of blood vessels do important work such as controlling blood pressure.

Geldanamycin offers a novel and potentially safer solution because it suppresses the protein indirectly.

The new study, based on experiments with human cells and different animal models, found that geldanamycin indirectly triggered the clearance of the VEGFR2 protein by activating a cellular quality-control system that breaks down many proteins.

That quality-control system already degrades VEGFR2 relatively slowly but the drug accelerates the process, preventing activation of the protein and inappropriate new blood vessel formation.

“With conventional treatments, we have been trying to deal with the situation after the switch has been thrown. What this drug does is destroy the key part of the switch before that switch is thrown,” Dr Ponnambalam said.

“Geldanamycin and chemical derivatives have been under intensive study in the laboratory and in clinical trials for the past 20 years. The cost to the NHS or patients could be relatively low compared to the expensive existing anti-cancer drugs, which are still under patent,” Dr Ponnambalam added.

The two-year study involved researchers in the University of Leeds and University College London. It was funded by The Wellcome Trust. The paper is published in the journal PLOS ONE.

 

The full paper: A.F Bruns N. Yuldasheva, A.M. Latham, Caroline Pellet-Many, L. Bao, P. Frankel, S.L. Stephen, G.J. Howell, S.B. Wheatcroft, M.T. Kearney, I.C. Zachary, S. Ponnambalam, “A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair.” PLOS ONE (2012)

The paper is available for download at http://dx.plos.org/10.1371/journal.pone.0048539 .

Contact: Chris Bunting, Press Officer, University of Leeds, Tel: +44 113 343 2049, Email: c.j.bunting@leeds.ac.uk

Source: University of Leeds

Photos (1)  [ view all photos ]


Reference: A.F Bruns N. Yuldasheva, A.M. Latham, Caroline Pellet-Many, L. Bao, P. Frankel, S.L. Stephen, G.J. Howell, S.B. Wheatcroft, M.T. Kearney, I.C. Zachary, S. Ponnambalam, “A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair.” PLOS ONE (2012) The paper is available for download at http://dx.plos.org/10.1371/journal.pone.0048539. Source: University of Leeds.

Related News:

Protein that accelerates age, brakes cancer 11 August 2013, 12:57
Prelamin A protein causes accelerated ageing disorders and also prevents the spread of cancer...

Study IDs key protein for cell death 16 May 2013, 04:32
Findings may offer a new way to kill cancer cells by forcing them into an alternative...

Proteome atlas for the tuberculosis pathogen 16 May 2013, 04:22
Researchers from ETH Zurich have mapped the coordinates for all the proteins of the tuberculosis...

Stem Cells for Metastasis Found in Blood of Breast Cancer Patients 30 April 2013, 08:43
For the first time, scientists from the German Cancer Research Center (DKFZ) and the National...

Mapping of cancer cell fuel pumps paves the way for new drugs 29 April 2013, 03:26
For the first time, researchers at Karolinska Institutet have managed to obtain detailed images...

Parkin protects from neuronal cell death 4 March 2013, 03:25
LMU researchers identify a novel signal transduction pathway, which activates the parkin gene...

Two new genes linked to amyotrophic lateral sclerosis (ALS) and... 4 March 2013, 03:18
St. Jude Children’s Research Hospital ties mutations in two genes to the death of motor...

Researchers Identify New Protein Biomarkers for Type 2 Diabetes 11 February 2013, 03:34
Neuherberg. Three proteins that can be measured in plasma correlate with type 2 diabetes and are...

IU researchers uncover protein's job protecting... 28 January 2013, 08:37
BLOOMINGTON, Ind. -- A team of chemists and biologists led by Indiana University chemistry...

Sensor of bacteria and viruses on high alert at the site of action 16 January 2013, 05:51
Researchers show: Sophisticated transport system helps immune cells quickly detect...

Credits / Source:

Reference: A.F Bruns N. Yuldasheva, A.M. Latham, Caroline Pellet-Many, L. Bao, P. Frankel, S.L. Stephen, G.J. Howell, S.B. Wheatcroft, M.T. Kearney, I.C. Zachary, S. Ponnambalam, “A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair.” PLOS ONE (2012) The paper is available for download at http://dx.plos.org/10.1371/journal.pone.0048539. Source: University of Leeds.