Strict Standards: Non-static method SEBenchmark::getInstance() should not be called statically in /home3/nextron/public_html/header.php on line 35

Strict Standards: Non-static method SESmarty::getInstance() should not be called statically in /home3/nextron/public_html/header.php on line 43

Strict Standards: Non-static method SEDatabase::getInstance() should not be called statically in /home3/nextron/public_html/header.php on line 96

Strict Standards: Non-static method SELanguage::info() should not be called statically in /home3/nextron/public_html/header.php on line 104

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 334

Strict Standards: Non-static method SELanguageStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/language.php on line 156

Strict Standards: Declaration of SELanguageStorageMysql::edit() should be compatible with SELanguageStorage::edit() in /home3/nextron/public_html/include/language/storage/mysql.php on line 255

Strict Standards: Declaration of SELanguageStorageMysql::get() should be compatible with SELanguageStorage::get() in /home3/nextron/public_html/include/language/storage/mysql.php on line 255

Strict Standards: Non-static method SECore::getSettings() should not be called statically in /home3/nextron/public_html/header.php on line 107

Strict Standards: Non-static method SECache::getInstance() should not be called statically in /home3/nextron/public_html/include/class_core.php on line 28

Strict Standards: Non-static method SECacheStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/cache/cache.php on line 66

Strict Standards: Non-static method SEDatabase::getInstance() should not be called statically in /home3/nextron/public_html/include/class_core.php on line 39

Strict Standards: Non-static method SECache::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_url.php on line 67

Strict Standards: Non-static method SECacheStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/cache/cache.php on line 66

Strict Standards: Non-static method SEDatabase::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_url.php on line 78

Strict Standards: Non-static method SELanguage::_preload_multi() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_datetime.php on line 35

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/language.php on line 529

Strict Standards: Non-static method SESession::getInstance() should not be called statically in /home3/nextron/public_html/header.php on line 125

Strict Standards: Non-static method SESessionStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/session/session.php on line 49

Strict Standards: Declaration of SESessionStorageNone::register() should be compatible with SESessionStorage::register($options = Array) in /home3/nextron/public_html/include/session/storage/none.php on line 16

Strict Standards: Non-static method SEDatabase::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/session/session.php on line 600

Strict Standards: Non-static method SESession::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_user.php on line 509

Strict Standards: Non-static method SESession::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_admin.php on line 208

Strict Standards: Non-static method SELanguage::select() should not be called statically in /home3/nextron/public_html/header.php on line 181

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 234

Strict Standards: Non-static method SELanguage::info() should not be called statically in /home3/nextron/public_html/header.php on line 183

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 334

Strict Standards: Non-static method SELanguage::info() should not be called statically in /home3/nextron/public_html/header.php on line 189

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 334

Strict Standards: Non-static method SECore::getPlugins() should not be called statically in /home3/nextron/public_html/header.php on line 229

Strict Standards: Non-static method SECache::getInstance() should not be called statically in /home3/nextron/public_html/include/class_core.php on line 62

Strict Standards: Non-static method SECacheStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/cache/cache.php on line 66

Strict Standards: Non-static method SEDatabase::getInstance() should not be called statically in /home3/nextron/public_html/include/class_core.php on line 73

Strict Standards: Declaration of rc_rssfeed::delete() should be compatible with rc_model::delete($id = NULL) in /home3/nextron/public_html/include/class_rssfeed.php on line 132

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 720

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 1087

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 1595

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 1636

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 1656

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 1756

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 1960

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2358

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2362

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2366

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2370

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2418

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2440

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2445

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2449

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2453

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2501

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2523

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2927

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2935

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2943

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2951

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 2959

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3300

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3304

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3308

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3312

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3373

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3395

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3434

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3456

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3461

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3465

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3469

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3473

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3783

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3815

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3845

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3868

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3879

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3889

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3911

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3925

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3952

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 3978

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4167

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4180

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4201

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4214

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4242

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4256

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4278

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4292

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4496

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4532

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4568

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4594

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4623

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4637

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4668

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4698

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4851

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4876

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4908

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4934

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 4988

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5117

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5153

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5186

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5217

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5321

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5353

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5392

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5428

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5463

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5498

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5505

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5790

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5794

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5798

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5802

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5850

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5872

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5877

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5881

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5885

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5933

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 5955

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 6392

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 7588

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 7649

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 7730

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 12921

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 12986

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 13011

Deprecated: Assigning the return value of new by reference is deprecated in /home3/nextron/public_html/include/class_radcodes_rss.php on line 13574

Strict Standards: Non-static method SELanguage::_preload_multi() should not be called statically in /home3/nextron/public_html/header_rssfeed.php on line 10

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 529

Strict Standards: Non-static method rc_toolkit::get_setting() should not be called statically in /home3/nextron/public_html/header_rssfeed.php on line 14

Strict Standards: Non-static method rc_toolkit::owner_level() should not be called statically in /home3/nextron/public_html/header_rssfeed.php on line 25

Strict Standards: Non-static method SELanguage::_preload_multi() should not be called statically in /home3/nextron/public_html/header_article.php on line 10

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 529

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_article.php on line 66

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_article.php on line 67

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SELanguage::_preload() should not be called statically in /home3/nextron/public_html/header_event.php on line 15

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 559

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_event.php on line 67

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_event.php on line 69

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_event.php on line 71

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_event.php on line 73

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_event.php on line 75

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SELanguage::_preload() should not be called statically in /home3/nextron/public_html/header_group.php on line 14

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 559

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_group.php on line 82

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_group.php on line 85

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_group.php on line 88

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SELanguage::_preload() should not be called statically in /home3/nextron/public_html/header_classified.php on line 15

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 559

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_classified.php on line 64

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_classified.php on line 66

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_classified.php on line 68

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_radcodes.php on line 10

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SELanguage::_preload_multi() should not be called statically in /home3/nextron/public_html/header_vid.php on line 15

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 529

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_vid.php on line 44

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SE_Hook::register() should not be called statically in /home3/nextron/public_html/header_vid.php on line 45

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 151

Strict Standards: Non-static method SELanguage::_preload_multi() should not be called statically in /home3/nextron/public_html/header_page.php on line 11

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 529

Strict Standards: Non-static method SELanguage::_preload_multi() should not be called statically in /home3/nextron/public_html/header_gmap.php on line 10

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 529

Strict Standards: Non-static method SE_Hook::exists() should not be called statically in /home3/nextron/public_html/header.php on line 298

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 246

Strict Standards: Non-static method SECache::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_user.php on line 280

Strict Standards: Non-static method SECacheStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/cache/cache.php on line 66

Strict Standards: Non-static method SEDatabase::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_user.php on line 291

Strict Standards: Non-static method SECache::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_user.php on line 320

Strict Standards: Non-static method SECacheStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/cache/cache.php on line 66

Strict Standards: Non-static method SEDatabase::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_user.php on line 331

Strict Standards: Non-static method SECache::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_user.php on line 200

Strict Standards: Non-static method SECacheStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/cache/cache.php on line 66

Strict Standards: Non-static method SEDatabase::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_user.php on line 211

Strict Standards: Non-static method SECache::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_user.php on line 240

Strict Standards: Non-static method SECacheStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/cache/cache.php on line 66

Strict Standards: Non-static method SEDatabase::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_user.php on line 251

Strict Standards: Non-static method SELanguage::_preload() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/class_user.php on line 179

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/language.php on line 559

Strict Standards: Non-static method SECore::getLanguages() should not be called statically in /home3/nextron/public_html/footer.php on line 14

Strict Standards: Non-static method SECache::getInstance() should not be called statically in /home3/nextron/public_html/include/class_core.php on line 96

Strict Standards: Non-static method SECacheStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/cache/cache.php on line 66

Strict Standards: Non-static method SELanguage::_languages() should not be called statically in /home3/nextron/public_html/include/class_core.php on line 110

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 366

Strict Standards: Non-static method SE_Hook::exists() should not be called statically in /home3/nextron/public_html/footer.php on line 29

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 246

Strict Standards: Non-static method SE_Hook::exists() should not be called statically in /home3/nextron/public_html/footer.php on line 32

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 246

Strict Standards: Non-static method SE_Hook::call() should not be called statically in /home3/nextron/public_html/footer.php on line 32

Strict Standards: Non-static method SE_Hook::create() should not be called statically in /home3/nextron/public_html/include/class_hook.php on line 272

Strict Standards: Non-static method SELanguage::info() should not be called statically in /home3/nextron/public_html/footer.php on line 58

Strict Standards: Non-static method SELanguage::_init() should not be called statically in /home3/nextron/public_html/include/language/language.php on line 334

Strict Standards: Non-static method SELanguage::_preload_multi() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/smarty/templates_c/%%86^861^861EA998%%article.tpl.php on line 6

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/language.php on line 529

Strict Standards: Non-static method SELanguage::load() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/smarty/templates_c/%%86^861^861EA998%%article.tpl.php on line 7

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/language.php on line 686

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/storage.php on line 192

Strict Standards: Non-static method SECache::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/storage.php on line 193

Strict Standards: Non-static method SECacheStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/cache/cache.php on line 66

Strict Standards: Only variables should be passed by reference in /home3/nextron/public_html/include/language/storage/mysql.php on line 177

Strict Standards: Non-static method SELanguage::_preload_multi() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/smarty/templates_c/%%05^053^053AB562%%header_article2.tpl.php on line 4

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/language.php on line 529

Strict Standards: Non-static method SELanguage::load() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/smarty/templates_c/%%05^053^053AB562%%header_article2.tpl.php on line 5

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/language.php on line 686

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/storage.php on line 169

Strict Standards: Non-static method SECache::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/storage.php on line 170

Strict Standards: Non-static method SECacheStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/cache/cache.php on line 66
MRC Scientists Identify Genes That Make MRSA Difficult To Beat - <br /> <b>Strict Standards</b>: Non-static method SELanguage::_get() should not be called statically, assuming $this from incompatible context in <b>/home3/nextron/public_html/include/smarty/templates_c/%%05^053^053AB562%%header_article2.tpl.php</b> on line <b>16</b><br /> <br /> <b>Strict Standards</b>: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in <b>/home3/nextron/public_html/include/language/language.php</b> on line <b>614</b><br /> insciences
Strict Standards: Non-static method SELanguage::_preload_multi() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/smarty/templates_c/%%87^870^870F1A81%%headerx.tpl.php on line 6

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/language.php on line 529

Strict Standards: Non-static method SELanguage::load() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/smarty/templates_c/%%87^870^870F1A81%%headerx.tpl.php on line 7

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/language.php on line 686
Keyword Tag Sort by


Categories: Bacteria Methicillin-resistant Staphylococcus aureus MRSA ftsH Ranalexin Antimicrobials Staphylococcal infections Genes

MRC Scientists Identify Genes That Make MRSA Difficult To Beat

Research at the Medical Research Council (MRC) has highlighted genes in the bacterium Methicillin-resistant Staphylococcus aureus (MRSA) that may help the superbug to survive after it has been targeted by antibacterial agents. This discovery could inform the development of future drugs to overcome MRSA’s defence systems.

The research team, including scientists at the MRC Human Genetics Unit in Edinburgh and the Universities of St Andrews, Dundee and London, developed a gene map to improve understanding of how MRSA escapes being killed by antimicrobials. For the first time, they were able to map relationships between 95 per cent of MRSA genes, and proposed possible new roles for 22 genes that help MRSA cause disease. One particular gene, ftsH, was singled out as a possible Achilles’ heel in MRSA and could potentially be a focus for new drug development.

As part of the study, researchers examined an antimicrobial agent called Ranalexin, which is derived from the skin of a bullfrog and kills MRSA. Computer analysis, coupled with laboratory tests on MRSA, showed that Ranalexin works by weakening both the bacterial cell wall and membrane. This information may help the development of new combination therapies.

MRSA is a particularly potent bacterial infection and the latest statistics show there were 781 deaths involving MRSA infection in 2009 in the UK - accounting for 62 per cent of deaths that involved Staphylococcus aureus - compared with 51 deaths in 1993. However, the proportion of MRSA infections in 2009 was lower than the peak level of 82 per cent in 2008. 'Methicillin-resistant' means the bacteria are unaffected by Methicillin, an antibiotic that could previously kill them.

In hospitals, the proportion of people made ill by MRSA is higher because of more contact with infected cases. People can carry MRSA for a few hours or days or sometimes for weeks or months. They are unaware they are carriers because the bacteria do not harm them or cause symptoms.

Dr Ian Overton at the MRC Human Genetics Unit is pleased with the results: “Multidrug resistant Staphylococcal infections such as MRSA are a worldwide problem and strains resistant to existing treatments continue to emerge. The development of new drugs is therefore important. Our network biology approach has given insights into how Ranalexin works to kill MRSA and helped us to understand more about how infections may develop. This knowledge contributes towards new strategies for treating MRSA.”

Professor Nick Hastie, Director of the MRC Human Genetics Unit, says: “This work is a fine example of the relationship between analysing the fundamental processes which help infections to take hold and exploiting this knowledge to improve drug treatments.”

This work was funded by the Biotechnology and Biological Sciences Research Council (BBSRC), Medical Research Council (MRC) and the Scottish Government, through a Royal Society of Edinburgh Personal Research Fellowship co-funded by Marie Curie Actions. The findings are published in BMC Systems Biology."

Contact: MRC Press Office, Tel: 0207 395 2345, Email: press.office@headoffice.mrc.ac.uk

Source: Medical Research Council (MRC)

Related News:

Genetic mutations warn of skin cancer risk 1 April 2014, 05:59
New high-risk cancer causing mutation identified for melanoma developmentResearchers have...

Detour leads to antibiotic resistance 1 April 2014, 05:54
LMU researchers have used cryo-electron microscopic imaging to characterize the structural...

Why Does Smallpox Vaccine Shield Some, Not Others? It's in the... 22 April 2013, 08:07
ROCHESTER, Minn. — How well people are protected by the smallpox vaccine depends on more than...

Parkin protects from neuronal cell death 4 March 2013, 03:25
LMU researchers identify a novel signal transduction pathway, which activates the parkin gene...

Two new genes linked to amyotrophic lateral sclerosis (ALS) and... 4 March 2013, 03:18
St. Jude Children’s Research Hospital ties mutations in two genes to the death of motor...

Bowel cancers reshuffle their genetic pack to cheat treatment 27 February 2013, 03:30
Bowel cancer cells missing one of three genes can rapidly reshuffle their genetic ‘pack of...

Study reveals molecular networks of mental health disorders 27 February 2013, 03:26
Early diagnosis and intervention for ADHD, autism and schizophrenia could be made possible after...

Bugs without borders: Researchers track the emergence and global... 10 December 2012, 08:34
Researchers show that the global epidemic of Clostridium difficile 027/NAP1/BI in the early to...

Gene switch important in cancer discovered 2 November 2012, 03:10
Scientists at Karolinska Institutet in Sweden and the University of Helsinki in Finland have...

Duke Blue Light Controls Gene Expression 1 October 2012, 13:36
New approach could greatly improve ability of researchers and physicians to control gene...

Sign up for daily newsletter

Subscribe to daily Science News
(a free e-mail delivery powered by Google)

Top Categories



Strict Standards: Non-static method SELanguage::load() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/smarty/templates_c/%%47^479^479B3B2F%%insciences.tpl.php on line 4

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/language.php on line 686

image

We have launched our peer- reviewed, Open-access journal: Insciences Journal

Recently added

27.11.12
Consequential Life Cycle Assessment of Nitrogen Fertilisers Based on Biomass – a Swedish perspective

08.11.12
From Molecular Hollows to Imprinting Strategies – Mass-Sensitive Devices in Host-Guest Chemistry

26.04.12
CdSe/ZnSe Quantum-Dot Semiconductor Optical Amplifiers

23.03.12
Screen-printed Electrochemical Sensors and Biosensors for Monitoring Metal Pollutants


 
 

Strict Standards: Non-static method SELanguage::load() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/smarty/templates_c/%%76^762^76224BF7%%footerx.tpl.php on line 6

Strict Standards: Non-static method SELanguage::_init() should not be called statically, assuming $this from incompatible context in /home3/nextron/public_html/include/language/language.php on line 686